BLK (E8T1B) Rabbit mAb

BLK is a Src family protein tyrosine kinase expressed in all stages of B cell development (1,2). Activation of B cells by various ligands is accompanied by activation of BLK (3). It has been suggested that BLK is involved in the control of B cell differentiation and proliferation (4,5). BLK transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that BLK may play an important role in thymopoiesis (6). BLK function may be redundant, however, as mice that do not express BLK are not impaired with respect to B cell development and immune response (7). 1.Dymecki, S.M. et al. (1990) Science 247, 332-336. 2.Wasserman, R. et al. (1995) J. Immunol. 155, 644-651. 3.Sefton, B.M. et al. (1994) Curr. Opin. Immunol. 6, 372-379. 4.Malek, S.N. et al. (1998) Proc. Natl. Acad. Sci. USA 95, 7351-7356. 5.Yao, X.R. et al. (1993) Proc. Natl. Acad. Sci. USA 90, 7946-7950. 6.Islam, K.B. et al. (1995) J. Immunol. 154, 1265-1272. 7.Texido, G. et al. (2000) Mol Cell Biol 20, 1227-33.