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产品介绍
产品介绍
产品信息
抗原名称
RNA polymerase I
商品描述
BMH-21 is a small molecule DNA intercalator that binds ribosomal DNA and inhibits RNA polymerase I transcription; does not cause phosphorylation of H2AX.
分子量
360.41
纯度
>98%
可溶性
DMSO : 1 mg/mL (2.77 mM; Need ultrasonic)
外观
light yellow to dark yellow powder
In vitro(体外研究)
BMH-21 causes proteasome-dependent destruction of RPA194, the large catalytic subunit protein of Pol I holocomplex. In U2OS cancer cell line, BMH-21 results in degradation of RPA194 and translocation of NCL with IC50 of 0.05 μM and 0.07 μM, respectively. By causing nucleolar stress, BMH-21 also shows potent inhibition on cell viability.
In vivo(体内研究)
BMH-21 reduces tumor growth in mouse xenografts.
背景
分子式
C21H20N4O2
CAS号
896705-16-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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