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BMS-191095 is mitochondrial ATP-sensitive potassium (mitoKATP) channel activator.
分子量
408.88
可溶性
DMSO:90 mg/mL (220.11 mM)
In vitro(体外研究)
BMS-191095 elicits a dose-dependent vasodilation in endothelium-denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively. BMS-191095 induces mitochondrial-depolarization and vasodilation.
In vivo(体内研究)
In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.
背景
分子式
C22H21ClN4O2
CAS号
166095-21-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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