BMS 345541 (10 mg)

9926054

Selective allosteric inhibitor of IKK; anti-inflammatory

291.78

N¹-(1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine hydrochloride

Selective allosteric inhibitor of IKK (IC₅₀ values are 0.3 and 4.0 μM for IKKβ and IKKα respectively). Exhibits no effect against a panel of 15 other kinases. Attenuates LPS-induced cytokine production in vitro and blocks NFκB dependent transcription in mice. Also suppresses joint destruction in a mouse model of arthritis.

≥99% (HPLC)

Soluble to 100 mM in water and to 100 mM in DMSO

NCCNC1=NC3=C(C=C(C)C=C3)N2C1=NC=C2C.Cl

C₁₄H₁₇N₅.HCl

547757-23-3