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产品介绍
产品介绍
产品信息
抗原名称
human FPR1:2800 nM (EC50), mouse FPR2:3.4 nM (EC50), human FPR2:0.41 nM (EC50)
商品描述
BMS-986235 is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the prevention of heart failure.
分子量
361.34
纯度
98%
可溶性
DMSO:95 mg/mL (262.91 mM)
In vitro(体外研究)
BMS-986235 inhibits neutrophil chemotaxis and stimulats macrophage phagocytosis, thereby promoting resolution of inflammation[1].
In vivo(体内研究)
In male C57BL/6 mice, BMS-986235 (0.3 mg/kg; p.o.) attenuates left ventricle and global cardiac remodeling after left anterior descending and reduces infarct length by 39% relative to the vehicle. BMS-986235 (1 mg/kg; p.o.) shows the Cmax, T1/2, AUC0-inf, and bioavailability (BA) values of 160 nmol/L, 0.68 hours,120 nmol/L•h, and 24%, respectively[1].
背景
分子式
C18H17F2N3O3
CAS号
2253947-47-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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