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商品描述
BMS-986242 is an orally active, potent and selective inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1), and it can be used for the research of cancer.
分子量
410.91
纯度
98%
可溶性
DMSO:250 mg/mL (608.41 mM)
In vitro(体外研究)
BMS-986242 is more prone to oxidative metabolism and less susceptible to glucuronidation. BMS-986242 exhibts IC50>25 μM for all targets except nAChR a1 (IC50=12.3 μM) and nAChR a7 (IC50>6 μM with ～20 % max inhibition).
In vivo(体内研究)
BMS-986242 (3~30 mg/kg; p.o.; 0~24 hours) shows dose-proportional exposure and a statistically significant reduction in kynurenine concentration in the tumor at all three doses
背景
分子式
C24H24ClFN2O
CAS号
1923844-48-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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