BMX, NT (Cytoplasmic Tyrosine-protein Kinase BMX, Bone Marrow Tyrosine Kinase Gene in Chromosome X Protein, ETK, Epithelial and Endothelial Tyrosine K

Affinity Purified Purified by immunoaffinity chromatography.

bmx

Synthetic peptide corresponding to human BMX.

BMX/ETK, a BTK/TEC type kinase, has been shown to affect the regulation of cellular processes including proliferation, differentiation, motility, apoptosis, and endocytosis. Etk contains an N-terminal Pleckstrin homology (PH) domain, a src homology 3 (SH3) domain, a src homology 2 (SH2) domain and a C-terminal tyrosine kinase (SH1) domain. The PH domains of Btk type kinases have been shown to bind to phospholipids as well as many protein partners including heterotrimeric G-proteins, PKC isoforms, Stat3, F-actin, Fas and FAK. Etk is activated by il-6 through phosphatidylinositol 3-kinase (pi3-kinase) pathway. It is likely that activation occurs through binding of phosphoinositides to the ph domain. It has been shown that Pak1 is a target of Etk and that Etk controls the proliferation as well as the anchorage-independent and tumorigenic growth of mammary epithelial cancer cells.

Supplied as a liquid in PBS (without Mg2+, Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.

Polyclonal

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Human

Anti -BMX, NT (Cytoplasmic Tyrosine-protein Kinase BMX, Bone Marrow Tyrosine Kinase Gene in Chromosome X Protein, ETK, Epithelial and Endothelial Tyrosine Kinase, NTK38)

660

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