BoNT/E (8B9)

鼠

抗-BoNT/E 抗体 8B9 是小鼠单克隆 IgG1，BoNT/E抗体，规格为100 µg/ml 免疫Clostridium botulinum物种的BoNT/E 推荐用于 Clostridium botulinum 来源的BoNT/E ELISA检测; 不会与 BoNT/A or BoNT/F产生交联反应 目前，我们还没有完成BoNT/E 抗体 (8B9)的首选二抗检测试剂的鉴定。这项工作正在进行中。 BoNT/E Antibody (8B9) is a high quality monoclonal BoNT/E antibody (also designated BoNT/E antibody) suitable for the detection of the BoNT/E protein of Clostridium botulinum origin. BoNT/E Antibody (8B9) is available as the non-conjugated anti-BoNT/E antibody. Botulism is a rare but serious paralytic illness caused by a nerve toxin, which is produced by the anaerobic bacillus Clostridium botulinum. This neuromuscular disorder occurs through a complex series of molecular events, ultimately ending with the arrest of acetylcholine (Ach) release and flaccid paralysis. Botulinum neurotoxin type E, also referred to as BoNT/E, cleaves synaptosomal-associated protein (SNAP-25) at the C-terminal domain releasing a 26-mer peptide. This peptide product may act as an excitation-secretion uncoupling peptide (ESUP) to inhibit vesicle fusion which causes a long (at least 3 weeks) halt of Ach release after the cleavage of SNAP-25. BoNT/E also inhibits glutamate release and blocks the spike activity of pyramidal neurons. BoNT/E treatment reduces both focal and generalized kainic acid-induced seizures and also prevents the neuronal loss and long-term cognitive deficits that are associated with these seizures.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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