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BOS-318
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产品介绍
产品介绍
产品信息
商品描述
BOS-318 is a Furin inhibitor with slowly dissociating, highly selective, and cell-pemeable characteristcs.
分子量
571.50
纯度
98%
可溶性
DMSO:45 mg/mL (78.74 mM)
In vitro(体外研究)
BOS-318 (0.001-1 μM) provides cytoprotection against toxicity in CuFi-1 cells induced by P aeruginosa exotoxin A (PEA). BOS-318 (U2OS cells) to be approximately 13 times more potent against furin than PCSK5 (IC50 = 25.3 nM), 24 times more potent that PCSK7 (IC50 = 45.8 nM), and 110 times more potent than PCSK6 (IC50 = 209.4 nM). BOS-318 (0.3 μM, 2h or 48 h)reduces ENaC-mediated Na+ absorption in CF HBECs and protects aganist NE- and CF sputum-sol-mediated activation of ENaC. [1]
背景
分子式
C28H32Cl2N6O3
CAS号
2387633-15-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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