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产品介绍
产品介绍
产品信息
抗原名称
HDAC6 ,HDAC8
商品描述
BRD-73954 is a biochemical inhibitor histone deacetylase cancer histone modification epigenetics gene regulation small molecule HDAC6 HDAC8.
分子量
284.3
纯度
>98%
可溶性
DMSO 56 mg/mL (196.96 mM)
Ethanol 9 mg/mL warmed (31.65 mM)
Ethanol 9 mg/mL warmed (31.65 mM)
外观
Powder
In vitro(体外研究)
As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation.
背景
别名
BRD-73954，BRD 73954
分子式
C16H16N2O3
CAS号
1440209-96-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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