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产品介绍
产品介绍
产品信息
纯化方式
>95% (HPLC)
抗原名称
α7, α1/β1/γ/δ nAChR and GABA(A) receptor subtypes
序列号
IVCHTTATSPISAVTCPPGENLCYRKMWCDAFCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG.
产品详情
A Potent Blocker of α7 and Muscle nAChR and GABA(A) Receptor Subtypes Conjugated to the Fluorescent Dye FITC
商品描述
α-Bungarotoxin-FITC (#B-100-F) is a highly pure, natural, and biologically active conjugated peptide toxin.
分子量
~8406 Da
生物活性
α-Bungarotoxin blocks postsynaptic neuromuscular transmission via competitive inhibition of nicotinic ACh receptors (nAChRs), thereby preventing the depolarizing action on postsynaptic membranes and blocking neuromuscular transmission. Selective for α7 receptors (IC50 value of 1.6 nM) and α3/β4 receptors (IC50 value of >3 μM)1,2. The toxin also blocks GABA(A) receptor subtypes3.
可溶性
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min). Avoid exposure to light.
浓度
1 nM - 3 μM.
形式
Lyophilized
背景
别名
Long neurotoxin 1, α-Bgtx, α-BuTX
翻译后修饰
Disulfide bonds between Cys3-Cys23, Cys16-Cys44, Cys29-Cys33, Cys48-Cys and Cys60-Cys65.
制备和贮存
存储溶液
Up to two weeks at 4°C or three months at -20°C. Avoid exposure to light.
保存方式
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Avoid exposure to light.
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