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Cabotegravir
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产品介绍
产品介绍
产品信息
抗原名称
HIV integrase
商品描述
Cabotegravir (GSK744, GSK1265744) is a long-acting HIV integrase inhibitor against a broad range of HIV subtypes, and inhibits the HIV-1 integrase catalyzed strand transfer reaction with IC50 of 3.0 nM. Phase 2.
分子量
405.35
纯度
98%
可溶性
DMSO : 16.67 mg/mL (41.12 mM; Need ultrasonic)
外观
White off off white crystalline powder
In vitro(体外研究)
GSK1265744 inhibits HIV replication with EC50 of 0.22 nM and 0.34-1.3 nM against HIV-1 Ba-L and NL432, respectively. GSK1265744 produces cytotoxicity with CC50 of 6.4, 5.0, 9.2, and 13 μM in proliferating IM-9, U-937, MT-4, and Molt-4 cell lines, respectively.
In vivo(体内研究)
GSK1265744 (50 mg/kg) treatment protects rhesus macaques against three high-dose SHIV challenges.
背景
别名
卡博特韦
分子式
C19H17F2N3O5
CAS号
1051375-10-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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