全部商品分类
CACNA1C
品牌： Usbiological
用小程序，查商品更便捷
收藏
对比
咨询纯度：
Purified by Protein G affinity chromatography.
反应种属：
Rabbit
产品介绍
产品介绍
产品信息
抗原来源
Human
宿主
Rabbit
免疫原
Recombinant protein corresponding to aa1755-1971 from human voltage-dependent L-type calcium channel subunit alpha-1C protein.
产品用途
Suitable for use in ELISA, Immunohistochemistry and Immunofluorescence. Other applications not tested.
简单描述
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.
同种型
IgG
克隆类别
Polyclonal
纯度
Purified by Protein G affinity chromatography.
形式
Supplied as a liquid in 0.01M PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
应用
实验应用
E IF IHC
推荐用量
Immunohistochemistry: 1:20-1:200 Immunofluorescence: 1:200-1:500 Optimal dilutions to be determined by the researcher..
反应种属
Rabbit
交叉反应性
Hu
目标/特异性
Recognizes human CACNA1C.
稀释度
Immunohistochemistry: 1:20-1:200 Immunofluorescence: 1:200-1:500 Optimal dilutions to be determined by the researcher..
背景
别名
Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2), CACNA1C, CACH2 CACN2 CACNL1A1 CCHL1A1
制备和贮存
保存方式
Storage_Temp:-20°C
Storage_and_Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
数据库链接
UniProt ID
Q13936
SwissProt
Q13936
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。