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产品介绍
产品介绍
产品信息
抗原名称
AT1 receptor
商品描述
Candesartan 是angiotensin II(血管紧张素II)受体拮抗剂， IC50为0.26 nM。Candesartan 作用于CHO-AT1细胞，高特异性地与血管紧张素II AT1 受体结合，K−1 为0.001 min−1。 在 KU-19-19细胞培养基中加入Candesartan，不影响细胞活力或细胞增殖，但提高VEGF和和白细胞介素-8的表达。 Candesartan (0.1 nM)可以降低对血管紧张素II的最大收缩反应，降低约50％。
分子量
440.45
纯度
>98%
可溶性
Ethanol ：0.4 mg/mL (10 mM) with gentle warming
DMSO ：4.5 mg/mL (100 mM)
DMSO ：4.5 mg/mL (100 mM)
外观
白色结晶性粉末
In vitro(体外研究)
Candesartan binds with high specificity to the angiotensin II AT1 receptors in CHO-AT1 cells with K−1 of 0.001 min−1. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.
In vivo(体内研究)
Candesartan (10 mg/kg) inhibits the growth of engrafted tumors and reduces the microvessel density and VEGF expression in a mouse KU-19-19 xenograft model Candesartan (0.5 mg/kg) decreases blood pressure and inhibits AT1 binding in the subfornical organ (SFO), paraventricular nucleus of the hypothalamus (PVN), nucleus of the solitary tract (NTS) and area postrema (AP) in WKY rats. Candesartan (0.3 mg/kg) pretreatment decreases the infarct area by 31% in adult spontaneously hypertensive rats, reduces the CBF decrease at the peripheral area of ischemia and the cortical volume of severe ischemic lesion.
背景
别名
坎地沙坦；CV 11974
分子式
C24H20N6O3
CAS号
139481-59-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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