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产品介绍
产品介绍
产品信息
抗原名称
P2Y12 receptor
商品描述
Cangrelor is a potent, competitive P2Y12 receptor inhibitor that is administered by intravenous infusion and rapidly achieves near complete inhibition of ADP-induced platelet aggregation.
分子量
864.29
纯度
98%
可溶性
DMSO ：2 mg/mL (2.31 mM)
Water ：100 mg/mL (115.70 mM)
Water ：100 mg/mL (115.70 mM)
外观
powder
In vitro(体外研究)
Cangrelor is an intravenous ATP analog that directly inhibits, without the need for being metabolized, the P2Y12 receptor in a reversible manner. Cangrelor has a rapid-onset and -offset mechanism of action and achieves significantly greater degrees of platelet inhibition compared with clopidogrel.
In vivo(体内研究)
Cangrelor is rapidly deactivated by plasmatic ectonucleotidases and, thus, has an extrmely short half-life (2-5 min). Preclinical studies performed in animal models in the early stages of cangrelor development show efficacy in inhibiting thrombus formation and ADP-induced platelet aggregation, as well as a lower increase of bleeding times when compared with IIb/IIIa antagonist.
背景
别名
坎格雷洛四钠盐；AR-C69931MX；AR-C69931
分子式
C17H21Cl2F3N5Na4O12P3S2
CAS号
163706-36-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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