Capsazepine (10 mg)

2733484

TRPV antagonist; also activator of ENaCδ

376.9

N-[2-(4-Chlorophenyl)ethyl]-1,3,4,5-tetrahydro-7,8-dihydroxy-2H-2-benzazepine-2-carbothioamide

Selective vanilloid receptor antagonist (K_i = 3.2 μM). Inhibits carrageenan inflammation-induced hyperalgesic responses in the rat. Also activates amiloride-sensitive epithelial Na⁺ channel ENaCδ. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™.

≥99% (HPLC)

Soluble to 25 mM in ethanol and to 100 mM in DMSO

OC1=C(O)C=C2CN(CCCC2=C1)C(=S)NCCC1=CC=C(Cl)C=C1

C₁₉H₂₁ClN₂O₂S

138977-28-3