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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
Caspase-8
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxyl terminus of human caspase-8 protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:50 - 1:250 |
同种型
Rabbit IgG
分子量
10, 57
内毒素水平
猪
研究领域
癌症,细胞生物学,纤维化,神经科学,
应用
反应种属
Human,Mouse,Rat,
预测反应种属
Pig
目标/特异性
Specificity/Sensitivity
Caspase-8 (D35G2) Rabbit mAb detects endogenous levels of total caspase-8, including the p10 subunit of the activated protein. Caspase-8 (D35G2) Rabbit mAb may also cross-react with overexpressed levels of caspase-10.
Species Reactivity:
Human, Mouse, Rat
敏感性
Endogenous
背景
背景
Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.
1.Muzio, M. et al. (1996) Cell 85, 817-27.
2.Boldin, M.P. et al. (1996) Cell 85, 803-15.
3.Fernandes-Alnemri, T. et al. (1996) Proc Natl Acad Sci U S A 93, 7464-9.
研究领域
癌症,细胞生物学,纤维化,神经科学,
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
841
UniProt ID
Q14790
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