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Cleaved Caspase-8 (Asp384) (11G10) Mouse mAb

品牌： CST

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参数

分子量：

反应种属：

Human

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产品介绍

产品信息

抗原名称

Cleaved Caspase-8

来源纯化

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of p10 of human caspase-8. Antibody is supplied in HEPES buffer with 50% glycerol and less than 0.02% sodium azide.

宿主

Mouse

简单描述

Monoclonal Antibody for studying Casp8 (Asp384) cleaved. Cited in 75 publications. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Cleaved Caspase-8 (Asp384) (11G10) Mouse Monoclonal Antibody (CST #9748) is ready to ship.

商品描述

Product Usage Information

Application	Dilution
Western Blotting	1:1000

分子量

研究领域

癌症,细胞生物学,纤维化,神经科学,

应用

反应种属

Human

目标/特异性

Specificity/Sensitivity

Cleaved Caspase-8 (Asp384) (11G10) Mouse mAb detects endogenous levels of the small fragment of caspase-8 resulting from cleavage at aspartic acid 384. The antibody does not cross-react with full length caspase-8.

Species Reactivity:

Human

敏感性

Endogenous

背景

Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.(This product is sold under license from Promega Corp., U.S. Patent No. 6,350,452.) 1.Muzio, M. et al. (1996) Cell 85, 817-27. 2.Boldin, M.P. et al. (1996) Cell 85, 803-15. 3.Fernandes-Alnemri, T. et al. (1996) Proc Natl Acad Sci U S A 93, 7464-9.

研究领域

癌症,细胞生物学,纤维化,神经科学,

翻译后修饰

Cleaved

制备和贮存

保存方式

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

数据库链接

Entrez-Gene ID

841

UniProt ID

Q14790

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货号：

9748T

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20ul

100ul

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