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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
抗原名称
Cleaved Caspase-8
来源纯化
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of p10 of human caspase-8. Antibody is supplied in HEPES buffer with 50% glycerol and less than 0.02% sodium azide.
宿主
Mouse
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
同种型
Mouse IgG1
分子量
10
研究领域
癌症,细胞生物学,纤维化,神经科学,
应用
反应种属
Human
目标/特异性
Specificity/Sensitivity
Cleaved Caspase-8 (Asp384) (11G10) Mouse mAb detects endogenous levels of the small fragment of caspase-8 resulting from cleavage at aspartic acid 384. The antibody does not cross-react with full length caspase-8.
Species Reactivity:
Human
敏感性
Endogenous
背景
背景
Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.(This product is sold under license from Promega Corp., U.S. Patent No. 6,350,452.)
1.Muzio, M. et al. (1996) Cell 85, 817-27.
2.Boldin, M.P. et al. (1996) Cell 85, 803-15.
3.Fernandes-Alnemri, T. et al. (1996) Proc Natl Acad Sci U S A 93, 7464-9.
研究领域
癌症,细胞生物学,纤维化,神经科学,
翻译后修饰
cleaved
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
841
UniProt ID
Q14790
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