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Ac-YVAD-CMK
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产品介绍
产品介绍
产品信息
抗原名称
Caspase-1
商品描述
Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases.
分子量
541.01
纯度
98%
可溶性
DMSO : 100 mg/mL (184.85 mM; Need ultrasonic)
外观
white to off-white powder
In vitro(体外研究)
Ac-YVAD-cmk (40 μM or 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia in vitro.
In vivo(体内研究)
Ac-YVAD-cmk treatment (1 μg/rats; SD rat; injected into the left lateral ventricle) significantly decreases the protein levels of caspase-1 (p20), mature IL-1β/IL-18 compared with the ICH group.
背景
分子式
C24H33ClN4O8
CAS号
178603-78-6
制备和贮存
保存方式
Store at -20℃ for three years（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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