Cathepsin B (D1C7Y) Rabbit mAb

Cathepsin B (CSTB), part of the papain family of proteases, is a widely expressed lysosomal cysteine endopeptidase (1,2). Cathepsin B is produced from a larger precursor form, pro-cathepsin B, which runs at approximately 44 kDa on SDS-PAGE, and is proteolytically processed and glycosylated to form a mature two-chain protein containing a heavy chain (running at 27 and 24 kDa) and a light chain (5 kDa). High levels of cathepsin B are found in macrophages and osteoclasts, as well as various types of cancer cells, including lung, colon, prostate, breast, and stomach. In addition, expression of cathepsin B has been associated with multiple sclerosis (3), rheumatoid arthritis (4), and pancreatitis (5). While generally localized to lysosomes, in cancer alterations can lead to its secretion (6). Its role in tumor progression is thought to involve promotion of basement membrane degradation, invasion and metastasis (7,8). Expression can correlate with poor prognosis for a variety of forms of cancer (9-13).This product detects a SARS-CoV-2-related target for research into the mechanisms of the Novel Coronavirus, which has caused the COVID-19 pandemic. 1.Chan, S.J. et al. (1986) Proc Natl Acad Sci USA 83, 7721-5. 2.Fong, D. et al. (1986) Proc Natl Acad Sci USA 83, 2909-13. 3.Bever, C.T. et al. (1994) Neurology 44, 745-8. 4.Hashimoto, Y. et al. (2001) Biochem Biophys Res Commun 283, 334-9. 5.Halangk, W. et al. (2000) J Clin Invest 106, 773-81. 6.Berquin, I.M. and Sloane, B.F. (1996) Adv Exp Med Biol 389, 281-94. 7.Yan, S. et al. (1998) Biol Chem 379, 113-23. 8.Vasiljeva, O. et al. (2006) Cancer Res 66, 5242-50. 9.Campo, E. et al. (1994) Am J Pathol 145, 301-9. 10.Foekens, J.A. et al. (1998) J Clin Oncol 16, 1013-21. 11.Werle, B. et al. (1999) Br J Cancer 81, 510-9. 12.Lah, T.T. et al. (2000) Clin Cancer Res 6, 578-84. 13.Werle, B. et al. (2000) Cancer 89, 2282-91.