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Cathepsin D Antibody

Cathepsin D Antibody

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分子量:
46, 43, 28
反应种属:
Human,Monkey,
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产品介绍
产品介绍
产品信息
荧光素标记
抗原名称
Cathepsin D
来源纯化

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues with the heavy chain subunit of human Cathepsin D. Antibodies are purified by protein A and peptide affinity chromatography.

宿主
Rabbit
商品描述

Product Usage Information

ApplicationDilution
Western Blotting1:1000
分子量
46, 43, 28
研究领域
神经科学
应用
反应种属
Human,Monkey,
目标/特异性

Specificity/Sensitivity

Cathepsin D Antibody detects endogenous levels of preprocathepsin D, procathepsin D and the heavy chain subunit of mature cathepsin D.

Species Reactivity:

Human, Monkey

敏感性
Endogenous
背景
背景
Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins (1). It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively) (2). Cathepsin D may also be secreted into the cytosol during apoptosis and contribute to cleavage of substrates implicated in the apoptotic pathway (3). Numerous studies have suggested that cathepsin D plays a role in neuronal degradation and malignant transformation, particularly in breast cancer (4-9). 1.Faust, P.L. et al. (1985) Proc. Natl. Acad. Sci. USA 82, 4910-4. 2.Erickson, A.H. et al. (1981) J. Biol .Chem. 256, 11224-31. 3.Liaudet-Coopman, E. et al. (2006) Cancer Lett. 237, 167-79. 4.Berchem, G. et al. (2002) Oncogene 21, 5951-5. 5.Nomura, T. and Katunuma, N. (2005) J. Med. Invest. 52, 1-9. 6.Garcia, M. et al. (1996) Stem Cells 14, 642-50. 7.Nogami, M. et al. (2000) Histochem. J. 32, 505-8. 8.Nakanishi, H. (2003) Ageing Res. Rev. 2, 367-81. 9.Callahan, L.M. et al. Neurobiol. Aging 19, S99-105.
研究领域
神经科学
翻译后修饰
unmodified
制备和贮存
保存方式

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

数据库链接
Entrez-Gene ID
1509
UniProt ID
P07339

参考图片

Western blot analysis of extracts from PANC1, SNB19 and MCF-7 cell lines using Cathepsin D Antibody.

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货号:
2284S
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询价
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100ul
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