

产品介绍
产品介绍
产品信息
荧光素标记
抗原名称
Cathepsin D

来源纯化
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues with the heavy chain subunit of human Cathepsin D. Antibodies are purified by protein A and peptide affinity chromatography.

宿主
Rabbit

商品描述
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |

分子量
46, 43, 28

研究领域
神经科学

应用
反应种属
Human,Monkey,

目标/特异性
Specificity/Sensitivity
Cathepsin D Antibody detects endogenous levels of preprocathepsin D, procathepsin D and the heavy chain subunit of mature cathepsin D.
Species Reactivity:
Human, Monkey

敏感性
Endogenous

背景
背景
Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins (1). It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively) (2). Cathepsin D may also be secreted into the cytosol during apoptosis and contribute to cleavage of substrates implicated in the apoptotic pathway (3). Numerous studies have suggested that cathepsin D plays a role in neuronal degradation and malignant transformation, particularly in breast cancer (4-9).
1.Faust, P.L. et al. (1985) Proc. Natl. Acad. Sci. USA 82, 4910-4.
2.Erickson, A.H. et al. (1981) J. Biol .Chem. 256, 11224-31.
3.Liaudet-Coopman, E. et al. (2006) Cancer Lett. 237, 167-79.
4.Berchem, G. et al. (2002) Oncogene 21, 5951-5.
5.Nomura, T. and Katunuma, N. (2005) J. Med. Invest. 52, 1-9.
6.Garcia, M. et al. (1996) Stem Cells 14, 642-50.
7.Nogami, M. et al. (2000) Histochem. J. 32, 505-8.
8.Nakanishi, H. (2003) Ageing Res. Rev. 2, 367-81.
9.Callahan, L.M. et al. Neurobiol. Aging 19, S99-105.

研究领域
神经科学
翻译后修饰
unmodified

制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
1509

UniProt ID
P07339

参考图片
Western blot analysis of extracts from PANC1, SNB19 and MCF-7 cell lines using Cathepsin D Antibody.
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