CCPG1 (E3C5G) Rabbit mAb

CCPG1 (cell cycle progression protein 1) was originally identified as a scaffold protein for Rho- specific guanine nucleotide exchange specificity (1). More recently it has been shown to play an important role in ER homeostasis by functioning as a cargo receptor for ER selective autophagy, termed ER-phagy (2). CCPG1 is localized to the ER and is induced by stress (2, 3). It associates with components of autophagy including LC3 family members and the FIP200, a component of the ULK1 complex, facilitating the trafficking of the ER to the autophagosome (2). 1.Kostenko, E.V. et al. (2006) Mol Cell Biol 26, 8964-75. 2.Smith, M.D. et al. (2018) Dev Cell 44, 217-232.e11. 3.Smith, M.D. and Wilkinson, S. (2018) Autophagy 14, 1090-1091.