hCCR7 MAb (25 ug)

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hCCR7 MAb (25 ug)

品牌： R&D Systems

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产品介绍

产品信息

荧光素标记

Unconjugated

抗原名称

BLR2， BLR2C-C chemokine receptor type 7， C-C CKR-7， CC-CKR-7， CCR7， CCR-7， CD197 antigen， CD197， CDw

宿主

Mouse IgG2a

克隆号

150503R-FAB2-TEV/His

Scientific Data

Flow Cytometry

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Detection of CCR7 in Human Lymphocytes by Flow Cytometry with anti-Mouse Secondary Antibody. Human peripheral blood lymphocytes were stained with (A) Mouse Anti-Human CCR7 FAB2 Recombinant Monoclonal Antibody (Catalog # MAB197R-FAB2) or (B) Mouse IgG2A isotype control antibody (MAB003), followed by APC-conjugated Anti-Mouse IgG Secondary Antibody (F0101B) and Mouse anti-Human CD4 PE-conjugated Monoclonal Antibody (FAB3791P). Staining was performed using our Staining Membrane-Associated Proteins protocol.

Flow Cytometry

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Detection of CCR7 in Human Lymphocytes by Flow Cytometry with anti-His antibody. Human peripheral blood lymphocytes were stained with (A) Mouse Anti-Human CCR7 FAB2 Recombinant Monoclonal Antibody (Catalog # MAB197R-FAB2) or (B) Mouse IgG2A isotype control antibody (MAB003), followed by PE-conjugated Anti-His Antibody (IC050P) and Mouse anti-Human CD4 APC-conjugated Monoclonal Antibody (FAB3791A). Staining was performed using our Staining Membrane-Associated Proteins protocol.

Human CCR7 Antibody Summary

Species Reactivity

Human

Specificity

Stains human CCR7 in flow cytometry

Source

Recombinant Monoclonal Mouse IgG_2A Clone # 150503R-FAB2-TEV/His

Purification

Protein A or G purified from cell culture supernatant

Immunogen

Human CCR7 transfectants
Met1-Pro378
Accession # AAA58615

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25 µg/10⁶ cells

PBMC lymphocytes

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

背景

别名

BLR2,BLR2C-C chemokine receptor type 7,C-C CKR-7,CC-CKR-7,CCR7,CCR-7,CD197 antigen,CD197,CDw197,CDw197CC chemokine receptor 7,chemokine (C-C motif) receptor 7,CMKBR7,CMKBR7chemokine (C-C) receptor 7,EBI1,EBI1EBV-induced G protein-coupled receptor 1,EBV-induced G-protein coupled receptor 1,Epstein-Barr virus induced gene 1,Epstein-Barr virus induced G-protein coupled receptor,Epstein-Barr virus-induced G-protein coupled receptor 1,EVI1,lymphocyte-specific G protein-coupled peptide receptor,MIP-3 beta receptor

背景

Background: CCR7

CCR7 (Chemokine Receptor 7; also CD197) is a 7 transmembrane (7TM) G protein-coupled chemokine receptor for the homeostatic chemokines CCL19/MIP-3 beta and CCL21/6Ckine. CCL19 and CCL21 are constitutively expressed by high endothelial venule epithelial cells or fibroblastic reticular cells in secondary lymphoid organs. CCR7 is upregulated on dendritic cells, naïve and memory T cells, Treg, NK cells, and B cells following inflammatory stimulation. Its expression enables the function of immune cell trafficking to and retention in regional lymph nodes for expansion of the adaptive immune response. Human CCR7 shares 87% amino acid sequence identity with mouse CCR7.

Entrez Gene IDs

1236 (Human); 12775 (Mouse); 287673 (Rat)

Alternate Names

BLR2; BLR2C-C chemokine receptor type 7; C-C CKR-7; CC-CKR-7; CCR7; CCR-7; CD197 antigen; CD197; CDw197; CDw197CC chemokine receptor 7; chemokine (C-C motif) receptor 7; CMKBR7; CMKBR7chemokine (C-C) receptor 7; EBI1; EBI1EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced gene 1; Epstein-Barr virus induced G-protein coupled receptor; Epstein-Barr virus-induced G-protein coupled receptor 1; EVI1; lymphocyte-specific G protein-coupled peptide receptor; MIP-3 beta receptor

研究领域

Related Research Areas

制备和贮存

保存方式

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

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货号：

MAB197R-FAB2-SP

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25ug

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