CD105/Endoglin (3A9) Mouse mAb (BSA and Azide Free)

CD105/Endoglin is an auxiliary receptor for the TGF-β receptor complex, functioning in related signaling pathways (1,2). CD105/Endoglin is a transmembrane protein that exists as a disulfide-linked homodimer. It is mainly expressed in vascular and connective tissues and in endothelial and stromal cells. Upregulated CD105/endoglin expression has been reported during wound healing and tumor vascularization, and in inflammatory tissues and developing embryos (1-4). Mutations in CD105/endoglin have been found to be a causal factor of hereditary hemorrhagic telangiectasia (HHT), a disease characterized by malformation of vascular structure (5,6). The importance of this protein for normal and tumor vascular function makes it a good marker for endothelial cell proliferation as well as a potential therapeutic target in cancer (4-6). 1.Bernabeu, C. et al. (2007) J Cell Biochem 102, 1375-88. 2.Zhu, Y. et al. (2003) Stroke 34, 2483-8. 3.Quintanilla, M. et al. (2003) Oncogene 22, 5976-85. 4.Dallas, N.A. et al. (2008) Clin Cancer Res 14, 1931-7. 5.ten Dijke, P. et al. (2008) Angiogenesis 11, 79-89. 6.Fernández-L, A. et al. (2006) Clin Med Res 4, 66-78.