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CD19 (Intracellular Domain) (D4V4B) CO-0054-594 SignalStar

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CD19 (Intracellular Domain) (D4V4B) CO-0054-594 SignalStar

品牌： CST

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产品介绍

产品信息

来源纯化

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu427 of human CD19 protein.

简单描述

SignalStar multiplex immunohistochemistry (IHC) is an advanced technology for labeling multiple proteins simultaneously in tissue samples using specific primary antibodies and fluorescent detection reagents. This technology offers accuracy and reliability in visualizing and analyzing protein expression while maintaining spatial context and tissue architecture.

SignalStar Oligo-Antibody Pairs are compatible with the SignalStar Multiplex IHC Buffer Kits for use in fluorescent multiplex imaging experiments. This product includes the oligo-conjugated antibodies and complementary oligos required for labeling your target protein on up to 10 slides. SignalStar Multiplex IHC Buffer Kits are required to amplify and image the target signal. Multiple oligo-antibody pairs can be conveniently combined into a multiplex panel using the SignalStar Multiplex IHC Panel Builder. SignalStar Multiplex IHC Kits & Reagents are not compatible with all of Cell Signaling Technology® products and protocols that are recommended for use in immunohistochemical assays.

商品描述

Product Usage Information

Application	Dilution
SignalStar™ Leica Bond	1:50 - 1:200
SignalStar™ Manual	1:50 - 1:200

应用

目标/特异性

Specificity/Sensitivity

CD19 (Intracellular Domain) (D4V4B) XP Rabbit mAb (SignalStar™ Conjugate 0054) recognizes endogenous levels of total CD19 protein.

Species Reactivity:

Human, Mouse

背景

CD19 is a 95 kDa coreceptor which amplifies the signaling cascade in B cells (1). On the B cell surface, CD19 associates with CD21, CD81, and Leu-13 to exert its function. The cytoplasmic tail of CD19 has nine conserved tyrosine residues playing critical roles in CD19 mediated function by coupling signaling molecules to the receptor (1). After B cell receptor or CD19 ligation, Tyr531 and Tyr500 of CD19 are progressively phosphorylated. This phosphorylation enables the coupling of PI3 kinase and Src family tyrosine kinase to CD19 and activates the PI3K and Src signaling pathways (2,3). Coligation of B cell receptor and CD19 also promotes Tyr409 phosphorylation in CD19. The phosphorylation at these sites enables its binding to Vav and mediates elevated intracellular calcium response, as well as the JNK pathway (4,5). 1.Tedder, T.F. et al. (1997) Immunity 6, 107-18. 2.Buhl, A.M. and Cambier, J.C. (1999) J Immunol 162, 4438-46. 3.Fujimoto, M. et al. (2000) Immunity 13, 47-57. 4.O'Rourke, L.M. et al. (1998) Immunity 8, 635-45. 5.Sato, S. et al. (1997) Proc Natl Acad Sci U S A 94, 13158-62.

翻译后修饰

unmodified

制备和贮存

保存方式

SignalStar conjugates are supplied in PBS (pH 7.2), less than 0.1% sodium azide, 2 mM EDTA, 0.05% Triton X-100, 2 mg/mL BSA, and 50% glycerol. Complementary oligos are supplied in nuclease-free water. Store at -20°C. Do not aliquot the antibody. All components in this kit are stable for at least 12 months when stored at the recommended temperature.

数据库链接

Entrez-Gene ID

930

UniProt ID

P15391

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货号：

65921S

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