2B4/SLAMF4/CD244 (D5J9D) Rabbit mAb

2B4, also known as signaling lymphocytic activation molecule family member 4 (SLAMF4) and cluster of differentiation 244 (CD244), is a heterophilic cell surface receptor expressed on a variety of immune cells, including natural killer (NK) cells, T cells, eosinophils, mast cells, and dendritic cells. 2B4 has been shown to have both immune stimulatory and inhibitory effects on cells (1-11). Upon engagement of its ligand CD48, 2B4 can enhance immune cell signaling, cytokine production, non-major histocompatibility complex-restricted cytotoxicity, and cell migration (1-8). Conversely, at early stages of NK cell differentiation, 2B4 may function as an inhibitory receptor possibly ensuring the self-tolerance of developing NK cells (10). 2B4 also inhibits inflammatory responses in dendritic cells (11). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. 1.Speiser, D.E. et al. (2001) J Immunol 167, 6165-70. 2.Nakajima, H. et al. (1999) Eur J Immunol 29, 1676-83. 3.Valiante, N.M. and Trinchieri, G. (1993) J Exp Med 178, 1397-406. 4.Munitz, A. et al. (2005) J Immunol 174, 110-8. 5.Sivori, S. et al. (2000) Eur J Immunol 30, 787-93. 6.El-Shazly, A.E. et al. Int J Immunopathol Pharmacol 24, 949-60. 7.Chen, L. and Flies, D.B. (2013) Nat Rev Immunol 13, 227-42. 8.Assarsson, E. et al. (2005) Mol Immunol 42, 419-23. 9.Elishmereni, M. et al. (2014) J Invest Dermatol 134, 2928-37. 10.Sivori, S. et al. (2002) Proc Natl Acad Sci U S A 99, 4526-31. 11.Georgoudaki, A.M. et al. (2015) Immunol Cell Biol 93, 581-90.