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BD Pharmingen™ APC Mouse anti-Human CD27

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BD Pharmingen™ APC Mouse anti-Human CD27

品牌： BD Pharmingen

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反应种属：

Human (QC Testing), Rhesus, Cynomolgus, Baboon (Tested in Development)

来源宿主：

Mouse BALB/c IgG1, κ

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产品介绍

产品信息

耦联标记

APC

抗原名称

CD27

宿主

Mouse BALB/c IgG1, κ

免疫原

Human T-CLL cells

简单描述

The M-T271 monoclonal antibody specifically binds to CD27. CD27 presents as a type I transmembrane, disulphide-linked 110 kDa homodimer comprised of two polypeptide chains. The CD27 molecule is a lymphocyte-specific member of the TNF/NGF-R family, and is expressed on a subset of human thymocytes and on the majority of mature T lymphocytes, activated B cells and NK cells. CD27 is highly induced on T cells after TCR stimulation. CD27 binds to CD70 (also known as, CD27 ligand or CD27L) and may be involved in cellular interaction of T and B lymphocytes.

商品描述

M-T271 The M-T271 monoclonal antibody specifically binds to CD27. CD27 presents as a type I transmembrane, disulphide-linked 110 kDa homodimer comprised of two polypeptide chains. The CD27 molecule is a lymphocyte-specific member of the TNF/NGF-R family, and is expressed on a subset of human thymocytes and on the majority of mature T lymphocytes, activated B cells and NK cells. CD27 is highly induced on T cells after TCR stimulation. CD27 binds to CD70 (also known as, CD27 ligand or CD27L) and may be involved in cellular interaction of T and B lymphocytes.

同种型

Mouse BALB/c IgG1, κ

克隆号

克隆 M-T271 (RUO)

产品详情

APC

Allophycocyanin (APC), is part of the BD family of phycobiliprotein dyes. This fluorochrome is a multimeric fluorescent phycobiliprotein with excitation maximum (Ex Max) of 651 nm and an emission maximum (Em Max) at 660 nm. APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter). Please ensure that your instrument’s configurations (lasers and optical filters) are appropriate for this dye.

格式:APC

激发源:Red 627-640 nm

最多激发源:651 nm

最多发射源:660 nm

应用

实验应用

Flow cytometry (Routinely Tested)

推荐用量

20 µl

反应种属

Human (QC Testing), Rhesus, Cynomolgus, Baboon (Tested in Development)

目标/特异性

CD27

背景

别名

TNFRSF7; TNF receptor superfamily, member 7; T14; Tp55; S152

制备和贮存

存储溶液

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

保存方式

Aqueous buffered solution containing BSA and ≤0.09% sodium azide.

文献

研发参考(4) 1. Bigler RD, Bushkin Y, Chiorazzi N. S152 (CD27). A modulating disulfide-linked T cell activation antigen. J Immunol. 1988; 141(1):21-28. (Biology). 2. Bigler RD, Donat TL, Boselli CM. Definition of three epitopes of the CD27 molecule [P 120->55] present on activated normal lymphocytes. In: Knapp W. W. Knapp .. et al., ed. Leucocyte typing IV : white cell differentiation antigens. Oxford New York: Oxford University Press; 1989:351-352. 3. Schlossman SF. Stuart F. Schlossman .. et al., ed. Leucocyte typing V : white cell differentiation antigens : proceedings of the fifth international workshop and conference held in Boston, USA, 3-7 November, 1993. Oxford: Oxford University Press; 1995. 4. Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol. 2005; 23:23-68. (Biology).

数据库链接

Entrez-Gene ID

939

参考图片

Flow cytometric analysis of CD27 on human peripheral blood lymphocytes. Whole blood was stained with either APC Mouse IgG1, κ Isotype Control (Cat. No. 555751; dashed line histogram) or APC Mouse Anti-Human CD27 (Cat. No. 558664/561786; solid line histogram). Erythrocytes were lysed with BD Pharm Lyse™ Lysing Buffer (Cat. No. 555899). Fluorescence histograms depicting CD27 (or Ig isotype control) expression were derived from gated events with the side and forward light-scattering characteristics of viable lymphocytes.

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货号：

558664

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