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产品介绍
产品介绍
产品信息
克隆号
RM27-3E5
Product Details
The RM27-3E5 monoclonal antibody reacts with mouse CD27, a 45 kDa type I transmembrane protein and a member of the TNF superfamily. CD27 is expressed on peripheral T cells, memory B cells, NK cells, and a subset of thymocytes. CD27 is highly induced on T cells after TCR stimulation. CD70 is a ligand for CD27. Interaction with CD70 provides co-stimulation in T cells and induces signaling events essential for cell proliferation, long-term maintenance of antigen-specific T cells, antiviral responses, antitumor immunity, and alloreactivity. Agonistic antibodies that stimulate CD27 are currently being explored as experimental cancer treatments. The RM27-3E5 antibody is an agonistic antibody that stimulates CD27 upon binding.Specifications
| Isotype | Rat IgG2a, κ |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb rat IgG2a isotype control, anti-trinitrophenol |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | Mouse CD27-human IgG1 Fc fusion protein |
| Reported Applications | in vivo CD27 stimulation in vitro CD27 stimulation Immunoprecipitation Flow cytometry |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein G |
| RRID | AB_2894767 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
抗小鼠跨膜蛋白27抗体，磷酸盐缓冲液
应用
反应种属
Mouse
背景
研究领域
Cancer Biology, Immune Checkpoint Protein, Immunology
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