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RecombiMAb anti-mouse CD4
品牌： BioXcell
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产品信息
克隆号
GK1.5-CP127
研究领域
免疫学和肿瘤学
Product Details
The GK1.5-CP127 monoclonal antibody is a chimeric version of the original GK1.5 antibody. The variable domain sequences are identical to the original GK1.5 but the constant region sequences have been switched from rat IgG2b to mouse IgG2b. The GK1.5-CP127 antibody contains no Fc mutations just as the original rat IgG2b antibody does not. The GK1.5-CP127 monoclonal antibody reacts with the mouse CD4. The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which in cooperation with the T cell receptor (TCR) interacts with class II MHC molecules displayed by antigen presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.Specifications
| Isotype | Mouse IgG2b, κ |
|---|---|
| Recommended Isotype Control(s) | InVivoPlus mouse IgG2b isotype control, unknown specificity |
| Recommended Dilution Buffer | InVivoPure pH 6.5 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | Mouse CTL clone V4 |
| Reported Applications | in vivo CD4+ T cell depletion* Flow cytometry* Western blot* *Reported for the original rat IgG2b GK1.5 antibody |
| Formulation | PBS, pH 6.5 Contains no stabilizers or preservatives |
| Endotoxin | <1EU/mg (<0.001EU/μg) Determined by LAL gel clotting assay |
| Aggregation | <5% Determined by DLS |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from CHO cell supernatant in an animal free facility |
| Purification | Protein G |
| Molecular Weight | 150 kDa |
| Murine Pathogen Tests | Ectromelia/Mousepox Virus: Negative Hantavirus: Negative K Virus: Negative Lactate Dehydrogenase-Elevating Virus: Negative Lymphocytic Choriomeningitis virus: Negative Mouse Adenovirus: Negative Mouse Cytomegalovirus: Negative Mouse Hepatitis Virus: Negative Mouse Minute Virus: Negative Mouse Norovirus: Negative Mouse Parvovirus: Negative Mouse Rotavirus: Negative Mycoplasma Pulmonis: Negative Pneumonia Virus of Mice: Negative Polyoma Virus: Negative Reovirus Screen: Negative Sendai Virus: Negative Theiler’s Murine Encephalomyelitis: Negative |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
抗CD4（细胞表面I型膜蛋白）抗体，磷酸盐缓冲液
背景
研究领域
Immunology
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