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产品介绍
产品介绍
产品信息
荧光素标记
Unconjugated
来源纯化
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the central region of human CD64/FcγRIA protein.
宿主
Rabbit
商品描述
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
同种型
Rabbit IgG
分子量
45-50, 60-80
应用
目标/特异性
Specificity/Sensitivity
CD64/FcγRIA (E6I4Z) Rabbit mAb recognizes endogenous levels of total CD64/FcγRIA protein. This antibody does not cross-react with FcγRIB protein.
Species Reactivity:
Human
敏感性
Endogenous
背景
背景
CD64/FcγRI (high affinity IgG Fc gamma RI) is an activating Fcγ receptor in the immunoglobulin superfamily, predominantly found on macrophages and monocytes (1-4). CD64 has a high affinity for the antibody-constant region of IgG, with three extracellular Ig-like domains (3). After binding IgG, CD64 interacts with an accessory chain known as the FcR common γ chain (FcRγ), which possesses an immunoreceptor tyrosine-based activation motif (ITAM) that is necessary for triggering cellular activation (2,3).
1.Fridman, W.H. et al. (1992) Immunol Rev 125, 49-76.
2.Perussia, B. et al. (1983) J Exp Med 158, 1092-113.
3.Nimmerjahn, F. and Ravetch, J.V. (2006) Immunity 24, 19-28.
4.Pincetic, A. et al. (2014) Nat Immunol 15, 707-16.
翻译后修饰
unmodified
制备和贮存
保存方式
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
数据库链接
Entrez-Gene ID
2209
UniProt ID
P12314
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