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InVivoMAb anti-mouse CD69
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InVivoMAb anti-mouse CD69

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品牌: BioXcell
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反应种属:
Mouse
来源宿主:
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产品信息
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Product Details

The CD69.2.2 monoclonal antibody reacts with mouse CD69, an 85 kDa type II C-type lectin. CD69 expression is rapidly induced upon cell activation in all leukocytes. CD69 is thought to be a negative regulator of the immune response in part through modulating the production of TGF-β. Studies in CD69-deficient mice have revealed that CD69 plays crucial roles in the pathogenesis of various inflammatory diseases including arthritis, asthma, and colitis. When administered in vivo the CD69.2.2 antibody causes CD69 to be internalized but does not deplete CD69+ cells. Anti-CD69-treated mice resemble CD69-/- mice to a remarkable degree. The CD69.2.2 antibody has been shown to activate NK cells in vivo and in vitro and promote anti-tumor responses.

Specifications

Isotype Mouse IgG1, κ
Recommended Isotype Control(s)InVivoMAb mouse IgG1 isotype control, unknown specificity
Recommended Dilution BufferInVivoPure pH 7.0 Dilution Buffer
Conjugation This product is unconjugated. Conjugation is available via our Antibody Conjugation Services.
Immunogen CD69+ murine 300-19 pre-B cells
Reported Applicationsin vivo down-regulation of CD69 expression
Functional assays
Formulation PBS, pH 7.0
Contains no stabilizers or preservatives
Endotoxin <2EU/mg (<0.002EU/μg)
Determined by LAL gel clotting assay
Purity >95%
Determined by SDS-PAGE
Sterility 0.2 µm filtration
Production Purified from cell culture supernatant in an animal-free facility
Purification Protein A
RRIDAB_2894750
Molecular Weight 150 kDa
Storage The antibody solution should be stored at the stock concentration at 4°C. Do not freeze.
组成成分
C型凝集素蛋白抗体,磷酸盐缓冲液
应用
反应种属
Mouse
背景
研究领域
Cancer Biology, Immunology
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货号:
BE0330-1MG
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