Phospho-CD79A (Tyr210) (E8E9Z) Rabbit mAb (PE Conjugate)

Antigen receptors found on the surface of B cells contain a heterodimeric signaling component composed of CD79A and CD79B, also known as Ig α and Ig β, respectively (1,2). Presence of this receptor complex is essential for B cell development and function (3). Together these two proteins and the associated B cell receptor (BCR) initiate intracellular signaling following antigen binding (4,5). An immunoreceptor tyrosine-based activation motif (ITAM) found in the CD79A intracellular region appears to be important for its function (6). Antigen binding precedes formation of the CD79A and CD79B heterodimer and subsequent activation of receptor associated kinases (7). Research has shown that CD79A is a marker for B-lineage lymphoblastic leukemia (8). Additionally, investigators have found that mutations in the CD79A (MB1) gene are associated with abnormally low levels of functional B cell receptors in some cases of chronic B cell lymphocytic leukemia (9).Tyrosine 210 is an evolutionarily conserved non-ITAM tyrosine residue that lies within the cytoplasmic domain of CD79A/Ig-α. Research studies have shown that ligation of the BCR induces phosphorylation of tyrosine 210, which facilitates both the recruitment of BLNK to the BCR signaling complex and the activation of downstream Syk-dependent signaling (10,11). Collectively, these molecular events drive B cell activation and proliferation (12). 1.van Noesel, C.J. et al. (1991) J Immunol 146, 3881-8. 2.Minegishi, Y. et al. (1999) J Clin Invest 104, 1115-21. 3.Yu, L.M. and Chang, T.W. (1992) J Immunol 148, 633-7. 4.Storch, B. et al. (2007) Eur J Immunol 37, 252-60. 5.Mason, D.Y. et al. (1995) Blood 86, 1453-9. 6.Luisiri, P. et al. (1996) J Biol Chem 271, 5158-63. 7.Pike, K.A. et al. (2004) J Immunol 172, 2210-8. 8.Astsaturov, I.A. et al. (1996) Leukemia 10, 769-73. 9.Vuillier, F. et al. (2005) Blood 105, 2933-40. 10.Engels, N. et al. (2001) Eur J Immunol 31, 2126-34. 11.Kabak, S. et al. (2002) Mol Cell Biol 22, 2524-35. 12.Patterson, H.C. et al. (2006) Immunity 25, 55-65.