CD86 (E2G8P) Rabbit mAb

CD80 (B7-1, BB1) and CD86 (B7-2, B70) are members of the B7 family of cell surface ligands that regulate T cell activation and immune responses. CD80 is expressed on activated antigen presenting cells, including dendritic cells, B cells, monocytes, and macrophages. CD86 is expressed on resting monocytes, dendritic cells, activated B lymphocytes, and can be further upregulated in the presence of inflammation (1-3). CD80 and CD86 are ligands for CD28, which functions as a T cell costimulatory receptor. Interaction of CD28 with CD80 or CD86 provides the second signal required for naïve T cell activation, T cell proliferation, and acquisition of effector functions (3-7). Alternatively, CD80 and CD86 also act as ligands to CTLA-4, which results in the downregulation of T cell activity (3,7-9). 1.Freeman, G.J. et al. (1989) J Immunol 143, 2714-22. 2.Azuma, M. et al. (1993) Nature 366, 76-9. 3.Adams, A.B. et al. (2016) J Immunol 197, 2045-50. 4.Linsley, P.S. et al. (1990) Proc Natl Acad Sci U S A 87, 5031-5. 5.Gimmi, C.D. et al. (1991) Proc Natl Acad Sci U S A 88, 6575-9. 6.Harding, F.A. et al. (1992) Nature 356, 607-9. 7.Collins, A.V. et al. (2002) Immunity 17, 201-10. 8.Linsley, P.S. et al. (1991) J Exp Med 174, 561-9. 9.Krummel, M.F. and Allison, J.P. (1995) J Exp Med 182, 459-65.