首页抗体一抗一抗

CD8alpha (D4W2Z) XP® Rabbit mAb

1/5

CD8alpha (D4W2Z) XP® Rabbit mAb

品牌： CST

下载产品说明书

下载COA

下载SDS

用小程序，查商品更便捷

对比

咨询

参数

分子量：

反应种属：

展开

产品介绍

产品信息

荧光素标记

Unconjugated

抗原名称

CD8alpha

来源纯化

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp42 of mouse CD8α protein.

宿主

Rabbit

商品描述

Product Usage Information

Application	Dilution
Western Blotting	1:1000
IHC Leica Bond	1:200 - 1:800
Immunohistochemistry (Paraffin)	1:200 - 1:800

同种型

Rabbit IgG

分子量

35-42

研究领域

癌症,纤维化,免疫学和肿瘤学,神经科学,

应用

反应种属

Mouse

目标/特异性

Specificity/Sensitivity

CD8α (D4W2Z) XP Rabbit mAb recognizes endogenous levels of total CD8α protein.

Species Reactivity:

Mouse

敏感性

Endogenous

背景

Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen–Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR–antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation (1). 1.Zamoyska, R. (1994) Immunity 1, 243-46.

研究领域

癌症,纤维化,免疫学和肿瘤学,神经科学,

翻译后修饰

unmodified

制备和贮存

保存方式

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

For a carrier free (BSA and azide free) version of this product see product #60168.

数据库链接

Entrez-Gene ID

12525

UniProt ID

P01731

参考图片

Multiplex immunohistochemical analysis of paraffin-embedded mouse LL2 syngeneic tumor tissue using CD8α (D4W2Z) XP® rabbit mAb (magenta), F4/80 (D2S9R) XP® rabbit mAb #70076 (orange), PD-1 (D7D5W) XP® rabbit mAb #84651 (green), PD-L1 (D5V3B) rabbit mAb #64988 (yellow), CD3ε (D4V8L) rabbit mAb #99940 (red) and pan keratin (C11) mouse mAb #4279 (cyan).

Western blot analysis of extracts from mouse CD8+ T cells, mouse spleen, EL4 cells, and Raw264.7 cells using CD8α (D4W2Z) XP® Rabbit mAb (upper), and β-Actin (D6A8) Rabbit mAb #8457 (lower).

Immunohistochemical analysis of paraffin-embedded mouse lung using CD8α (D4W2Z) XP® Rabbit mAb performed on the Leica® BOND™ Rx.

Immunohistochemical analysis of paraffin-embedded mouse spleen using CD8α (D4W2Z) XP® Rabbit mAb.

Immunohistochemical analysis of paraffin-embedded mouse small intestine using CD8α (D4W2Z) XP® Rabbit mAb.

声明：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。

货号：

98941T

一键复制

询价

优宁维现货

20ul

100ul

选择数量

当前规格1件起购

配送至

预计3-4个工作日送达，快递: 免运费，若需干冰额外收费

询价大包装询价