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产品介绍
产品介绍
产品信息
克隆号
DECMA-1
Product Details
The DECMA-1 monoclonal antibody reacts with the extracellular domain of mouse E-Cadherin, a 120-kDa transmembrane cell-cell adhesion glycoprotein also known as CD324 and uvomorulin. E-Cadherin is widely expressed on epithelial cells in the colon, uterus, liver, keratinocytes, brain, heart, muscle, kidney, and pancreas as well as erythroid cells. E-Cadherin is a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-to-cell adhesion. E-Cadherin is involved in development, bacterial pathogenesis, and tumor invasion. The DECMA-1 antibody has been shown to delay tumor onset and attenuate tumor burden in MMTV-PyMT mice by reducing tumor cell proliferation and inducing apoptosis without any detectable cytotoxicity.Specifications
| Isotype | Rat IgG1, κ |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb rat IgG1 isotype control, anti-horseradish peroxidase |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | Mouse PCC4azal teratocarcinoma cells |
| Reported Applications | in vivo E-Cadherin neutralization In vitro E-Cadherin neutralization Immunofluorescence Immunoprecipitation Western blot |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein G |
| RRID | AB_2894771 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
E钙粘蛋白抗体，磷酸盐缓冲液
应用
反应种属
Mouse
背景
研究领域
Apoptosis, Cancer Biology, Cell Migration & Adhesion, Immunology, Tumor Antigens
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