CDN 1163 (10 mg)

16016585

SERCA2 allosteric activator

320.38

4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide

SERCA2 allosteric activator. Increases Ca²⁺-ATPase activity and Ca²⁺ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice.

≥98% (HPLC)

Soluble to 100 mM in DMSO and to 100 mM in ethanol

CC1=NC2=C(NC(C3=CC=C(OC(C)C)C=C3)=O)C=CC=C2C=C1

C₂₀H₂₀N₂O₂

892711-75-0