CEACAM6 (E7S7Y) Rabbit mAb

Carcinoembryonic antigen (CEA)-related cell adhesion molecule 6 (CEACAM6) is a member of the CEA-related cell adhesion molecule (CEACAM) family (1). CEACAMs bind to themselves and other family members to carry out numerous cellular functions, including proliferation, signaling, differentiation, tumor suppression, and survival (2). CEACAM6 is a single-chain, glycosylphosphatidylinositol (GPI)-anchored, highly glycosylated protein that is normally expressed on epithelial cells and granulocytes (3,4). CEACAM6 mediates homophilic and heterophilic cell adhesion with other CEA-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (3-6). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (7), and plays a role in neutrophil adhesion to cytokine-activated endothelial cells (4). High levels of CEACAM6 expression are also observed in several different cancers (8-10). In cancer, CEACAM6 promotes tumor progression, migration, invasion, and metastasis, and therefore is considered a target for therapeutic intervention (11-13). 1.Kuespert, K. et al. (2006) Curr Opin Cell Biol 18, 565-71. 2.Bonsor, D.A. et al. (2015) Proc Natl Acad Sci U S A 112, 13561-6. 3.Kuroki, M. et al. (2001) J Leukoc Biol 70, 543-50. 4.Kuijpers, T.W. et al. (1992) J Cell Biol 118, 457-66. 5.Oikawa, S. et al. (1989) Biochem Biophys Res Commun 164, 39-45. 6.Oikawa, S. et al. (1991) J Biol Chem 266, 7995-8001. 7.Skubitz, K.M. et al. (1996) J Leukoc Biol 60, 106-17. 8.Duxbury, M.S. et al. (2004) Br J Cancer 91, 1384-90. 9.Schölzel, S. et al. (2000) Am J Pathol 156, 595-605. 10.Beauchemin, N. and Arabzadeh, A. (2013) Cancer Metastasis Rev 32, 643-71. 11.Zhang, Y. et al. (2014) Acta Biochim Biophys Sin (Shanghai) 46, 283-90. 12.Blumenthal, R.D. et al. (2005) Cancer Res 65, 8809-17. 13.Ru, G.Q. et al. (2017) Oncotarget 8, 83673-83683.