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产品介绍
产品信息
商品描述
Cevimeline hydrochloride hemihydrate, a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren‘s syndrome.
分子量
489.55
纯度
＞98%
可溶性
H2O : ≥ 50 mg/mL (204.27 mM)
外观
white to tan powder
In vitro(体外研究)
In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration.
In vivo(体内研究)
Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg.
背景
别名
盐酸西维美林半水合物；SNI-2011；AF102B hydrochloride hemihydrate
分子式
C20H38Cl2N2O3S2
CAS号
153504-70-2
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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