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产品介绍
产品介绍
产品信息
商品描述
Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro with EC50 of 1.13 μM.
分子量
319.87
纯度
98%
可溶性
DMSO : 100 mg/mL (312.63 mM)
外观
White to Light Brown Solid
In vitro(体外研究)
Chloroquine suppressed matrix metalloproteinase (MMP)-2 and MMP-9 mRNA expression and protein activity, whereas MMP-13 mRNA expression and proteolytic activity were increased.?Despite enhancing TLR9 mRNA expression, chloroquine suppressed TLR9 protein expression in vitro[1].
In vivo(体内研究)
Daily treatment of mice with intraperitoneal (i.p.) chloroquine (80 mg/kg/day) for 22 days, did not inhibit the growth of control siRNA or TLR9 siRNA MDA-MB-231 breast cancer cells[1].
背景
别名
氯喹
分子式
C18H26ClN3
CAS号
54-05-7
制备和贮存
保存方式
Store at -20℃ for three years（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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