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商品描述
Cholera toxin （CTB,霍乱毒素B亚基）belongs to the AB5 –subunit family oftoxins.The native hexameric protein has a molecular mass of ~85 kDa and contains two subunits. It consists of a single A subunit (~27.2 kDa), responsible for the ADP-ribosylation activity, and five B subunits(~11.6 kDa each), which are arranged as a pentameric ring with an apparent 5-fold symmetry and are associated with the cell surface receptor binding and subsequent internalization (transmembrane transport)of the enzymatic component.
分子量
11kd
纯度
≥95%
浓度
See the label for details.
外观
liquid
应用
反应种属
Human;Mouse;Rat;Pig;Zebrafish;Dog;Monkey;Fish
注意事项
The B subunit is non-toxic to cells and possesses no intrinsic adenylate cyclase activity. The cholera toxin B subunit (CTB) attaches to cells by binding to ganglioside GM1.8 CTB has been shown to be a good label for microglial cells (due to the enrichment of ganglioside GM1 on their cell surface), but not for oligodendrocytes or astrocytes. The B subunit has been reported to be an excellent tracer for the study of axonal transport using immunohistochemical methods. Recently it has been widely used as a marker of membrane lipid rafts, which are membrane microdomains enriched with cholestrol and sphingolipids. These lipid rafts have an important role in cell signaling and protein trafficking.
背景
别名
霍乱毒素B亚基-FITC、CHOLERA TOXIN B SUBUNIT-FITC、CTB-FITC、 Cholera Toxin B subunit-FITC、CTxB-FITC、Choleragenoid-FITC
技术指标
Format：Recombinant Source：E.coli Sodium azide：Not add.
CAS号
131096-89-4
制备和贮存
保存方式
store at -20 ℃ for one year.
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