Cilengitide (10 mg)

176873

RGDFV

(Modifications: Phe-4 = D-Phe, Val-5 = Me-Val, Cyclizedl)

Potent and selective inhibitor of integrins α_vβ₃ and α_vβ₅

588.66

Potent and selective inhibitor of integrins α_vβ₃ and α_vβ₅ (IC₅₀ values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.

≥95% (HPLC)

Soluble to 10 mg/ml in water

EMD121974

CC(C)[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C(=O)N1C)CC2=CC=CC=C2)CC(=O)O)CCCN=C(N)N

C₂₇H₄₀N₈O₇

188968-51-6