CINPA 1 (10 mg)

395.49

Potent CAR antagonist (IC₅₀ = 70 nM). Exhibits >90-fold selectivity for CAR over pregnane X receptor (PXR). Also selective over a panel of other nuclear receptors including FXR, LXR, PPARγ and RXR.

>98 %

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate

C₂₃H₂₉N₃O3