全部商品分类
.jpg)
1/2
用小程序，查商品更便捷
产品介绍
产品介绍
产品信息
商品描述
CL-82198 is a selective inhibitor of MMP-13. CL-82198 binds to the entire S1’ pocket of MMP-13, which is the basis for its selectivity towards MMP-13 and the lack of inhibitory activities against other MMPs. CL-82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression.
分子量
302.37
纯度
98%
可溶性
DMSO ：60 mg/mL (198.43 mM)
Ethanol ：60 mg/mL (198.43 mM)
Ethanol ：60 mg/mL (198.43 mM)
外观
white to off-white powder
In vitro(体外研究)
L-82198 (10 μM; 24 hours) significantly reduces LS174 cell migration.
CL-82198 decreases CTGF and TGF-β1 protein levels in hepatic stellate cells.
CL-82198 decreases CTGF and TGF-β1 protein levels in hepatic stellate cells.
In vivo(体内研究)
CL82198 (1-10 mg/kg; i.p.; every other day for 12 weeks) prevents and decelerates MLI-induced osteoarthritis progression.
背景
分子式
C17H22N2O3
CAS号
307002-71-7
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。