CNOT3 (D4K4N) Rabbit mAb

The evolutionarily conserved CCR4-NOT (CNOT) complex regulates mRNA metabolism in eukaryotic cells (1). This regulation occurs at different levels of mRNA synthesis and degradation, including transcription initiation, elongation, deadenylation, and degradation (1). Multiple components, including CNOT1, CNOT2, CNOT3, CNOT4, CNOT6, CNOT6L, CNOT7, CNOT8, CNOT9, and CNOT10 have been identified in this complex (2). In addition, subunit composition of this complex has been shown to vary among different tissues (3).Research studies indicate that CNOT3 (along with CNOT1 and CNOT2) represses early developmental transcription factor expression, helping to maintain embryonic stem (ES) cell identity in mice and humans (4). Additional studies suggest that CNOT3 plays a role in mitotic progression as it destabilizes mitotic spindle assembly protein MAD1 mRNA (5). Finally, CNOT3 appears to act as a modifier gene affecting the penetrance of mutations causing autosomal dominant retinitis pigmentosa (6) and as a tumor suppressor associated with cases of adult T-cell acute lymphoblastic leukemia (7). 1.Denis, C.L. and Chen, J. (2003) Prog Nucleic Acid Res Mol Biol 73, 221-50. 2.Lau, N.C. et al. (2009) Biochem J 422, 443-53. 3.Chen, C. et al. (2011) Biochem Biophys Res Commun 411, 360-4. 4.Zheng, X. et al. (2012) Stem Cells 30, 910-22. 5.Takahashi, A. et al. (2012) Biochem Biophys Res Commun 419, 268-73. 6.Venturini, G. et al. (2012) PLoS Genet 8, e1003040. 7.De Keersmaecker, K. et al. (2013) Nat Genet 45, 186-90.