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CNX-2006
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产品介绍
产品介绍
产品信息
抗原名称
mutant EGFR
商品描述
CNX-2006是一种新型，不可逆，突变选择性的EGFR抑制剂，IC50为<20 nM，对野生型EGFR有微弱的抑制作用。
分子量
545.53
纯度
>98%
可溶性
Ethanol ：28 mg/mL (51.3 mM)
DMSO ：93 mg/mL (170.5 mM)
DMSO ：93 mg/mL (170.5 mM)
In vitro(体外研究)
CNX-2006 is a novel irreversible EGFR tyrosine kinase inhibitor, specifically inhibits activating mutations of EGFR as well as the T790M mutation while having very weak inhibition at wild-type EGFR. In in vitro modeling of acquired resistance, continuous CNX-2006 treatment on drug-sensitive EGFR mutant cells leads to resistance more slowly than erlotinib. Dose escalation with CNX-2006 leads to differential effects in different lines, but does not select for T790M-mediated resistance. CNX-2006 resistent cells shows increased expression of EMT markers and MMP9.
In vivo(体内研究)
CNX-2006 is effective in H1975 (EGFR L858R/T790M) xenograft model.
背景
分子式
C26H27F4N7O2
CAS号
1375465-09-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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