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产品介绍
产品介绍
产品信息
抗原来源
Human
宿主
Mouse
免疫原
Purified recombinant protein fragment corresponding to aa1219-1464 from human COL1A1, expressed in E. coli.
产品用途
Suitable for use in ELISA, Flow Cytometry and Western Blot. Other applications not tested.
简单描述
This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
同种型
IgG1
克隆号
7B1G12
克隆类别
Monoclonal
纯度
Purified
形式
Supplied as a liquid in PBS, 0.05% sodium azide.
应用
实验应用
E FC WB
推荐用量
ELISA: 1:10,000 Flow Cytometry: 1:200-1:400 Western Blot: 1:500-1:2000 Optimal dilutions to be determined by the researcher.
反应种属
Mouse
交叉反应性
Hu
目标/特异性
Recognizes human COL1A1.
稀释度
ELISA: 1:10,000 Flow Cytometry: 1:200-1:400 Western Blot: 1:500-1:2000 Optimal dilutions to be determined by the researcher.
背景
别名
OI1; OI2; OI3; OI4; EDSC; EDSARTH1
制备和贮存
保存方式
Storage_Temp:-20°C
Storage_and_Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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