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CONNEXIN-26 (GJB2) ANTIBODY
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产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Defects in GJB3 have been linked to erythrokeratodermia variables (EKV) is an autosomal dominant genodermatosis characterized by transient figurate red patches or hyperkeratosis. Mutations in GJB2 have also been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: connexin 26; Connexin-26; Cx26; Gap junction beta-2 protein; gap junction channel protein connexin 26; gap junction membrane channel protein beta 2; gap junction protein, beta 2, 26kDa; mutant gap junction protein beta 2
基因别名: AI325222; Cnx26; CX26; CXN-26; DFNA3; DFNA3A; DFNB1; DFNB1A; Gjb-2; GJB2; HID; KID; NSRD1; PPK
UniProt ID:(Human) P29033, (Mouse) Q00977, (Rat) P21994
Entrez Gene ID:(Human) 2706, (Mouse) 14619, (Rat) 394266
参考图片
Expression of Connexin-26 in human HepG2 liver hepatocellular carcinoma cells - Immunocytochemical staining of fixed and permeabilized HepG2 liver hepatocellular carcinoma cells. A. Cells were stained with Anti-Connexin-26 (GJB2) Antibody (#ACC-212), (1:400), followed by goat Anti-rabbit-AlexaFluor-594 secondary Antibody (red). B. Cell nuclei were visualized using Hoechst 33342 (blue). C. Merge of the two images.
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) liver membranes: - 1,2. Anti-Connexin-26 (GJB2) Antibody (#ACC-212), (1:200).3,4. Anti-Connexin-26 (GJB2) Antibody , preincubated with Connexin-26/GJB2 Blocking Peptide (#BLP-CC212).