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COP1, NT (CARD16, COP, COP1, Caspase recruitment domain-containing protein 16, CARD only domain-containing protein 1, Caspase-1 inhibitor COP, Pseudo
品牌： MyBioSource
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对比
咨询反应种属：
Human
实验应用：
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
产品介绍
产品介绍
产品信息
纯化方式
Affinity Purified
Purified by Protein A affinity chromatography.
抗原名称
Cop1
免疫原
COP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-73 amino acids from the N-terminal region of human COP1.
商品描述
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
形式
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
产品类型
Polyclonal
应用
实验应用
ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)
反应种属
Human
背景
别名
Anti -COP1, NT (CARD16, COP, COP1, Caspase recruitment domain-containing protein 16, CARD only domain-containing protein 1, Caspase-1 inhibitor COP, Pseudo interleukin-1 beta converting enzyme)
制备和贮存
保存方式
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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