CP 154526 (10 mg)

11475094

Selective, non-peptide CRF₁ antagonist

400.99

N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride

Selective, non-peptide CRF₁ receptor antagonist (K_i values are 2.7 and > 10000 nM for CRF₁ and CRF₂ receptors respectively). Blocks CRF-induced adenylate cyclase activation (K_i = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant.

≥99% (HPLC)

Soluble to 50 mM in DMSO and to 50 mM in ethanol

CC1=CN(C3=C(C)C=C(C)C=C3C)C2=C1C(N(CC)CCCC)=NC(C)=N2.Cl

C₂₃H₃₂N₄.HCl

257639-98-8