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CP-66948
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产品介绍
产品介绍
产品信息
商品描述
CP-66948 is a potent histamine H2 receptor antagonist with inhibitory effect on gastric acid secretion and can be used to protect gastric and intestinal mucosa.
In vivo(体内研究)
CP-66,948 exhibits an affinity for the guinea pig atria histamine H2-receptor that is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED50 value for the inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally. In histamine or pentagastrin-stimulated Heidenhain pouch dogs, the antisecretory ED50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also demonstrates inhibition of ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration, with ED50 values of 12 mg/kg per os and 6 mg/kg subcutaneously[1].
背景
分子式
C13H20N6S
CAS号
101189-47-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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